Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. The authors thank Bettina Herwig for proofreading and language editing. https://doi.org/10.1007/s00330-016-4470-8 (2017). ; writingoriginal draft preparation, F.I. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the Receiver operating characteristic (ROC) curves were generated, and the area under the ROC curve was calculated to assess the diagnostic accuracy of rPET in detecting a positive response, along with the corresponding cut-off scores. PET/CT, however, is time Meignan, M., Gallamini, A., Meignan, M., Gallamini, A. 1993;341(8852):1051-1054. Harell, F. Jr. Hmisc: Harrell Miscellaneous. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Imaging 30, 13231341. HL is often curable by conventional chemotherapy and radiotherapy. Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. Reproducibility of radiomics for deciphering tumor phenotype with imaging. Role of CT density in PET/CT-based assessment of lymphoma. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 It would also have been desirable to obtain data from a more consistent patient population with a consistent therapy regimen and identical time points of PET/CT. Elhamady, H.Y. Mol. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. Bertuzzi, C., Sabattini, E. & Agostinelli, C. Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Support Center Find answers to questions about products, access, use, setup, and administration. Ann Oncol 2005;16:1514-23. Author to whom correspondence should be addressed. A bone marrow biopsy is now recommended only for diffuse large B-cell lymphoma with a negative PET-CT result.19. J.Nucl. From these segmentations, 107 features were extracted with PyRadiomics. and JavaScript. https://CRAN.R-project.org/package=Hmisc (2022). High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. Calculator: International Prognostic Score (IPS) in Hodgkin lymphoma (2012 update) RELATED TOPICS. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" qPETA quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Laura J. Jensen. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. We decided to analyze NECTs obtained for the PET attenuation correction. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. This content is owned by the AAFP. https://doi.org/10.1080/10428194.2020.1786555 (2020). suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. 75 PET/CT examinations of 43 patients on two different scanners were included. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). ; Zucca, E.; Lister, T.A. Four patients were PET positive at the end of ABVD Please review the contents of the article and, Barrington et al., Eur J Nucl Med Mol Imaging (2010) 37:18241833. Giesel, F. L. et al. It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. 58, 282287. Hodgkin's lymphoma. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. No special Flechsig, P. et al. Aleman, B.M.P. government site. Fedorov, A. et al. ; Contact Us Have a question, idea, or some feedback? Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). WebInterim PET/CT scan was performed after 23 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (SUVmax). The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Ibrahim, A. et al. PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. 2013;54(11):2531-2533. ; Unal, S.N. Frood, R. et al. Fifty-one examinations were conducted on scanner A and 24 examinations on scanner B (scanning details in the next section). Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). ; Birch, J.M. Rinsho Ketsueki. Epub 2018 Jul 21. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). Sci. Chih-Yang Hsu, Mike Doubrovin, John T. Lucas Jr. Scientific Reports Standard of Care is available as a free resource for practicing medical professionals, students and the general public. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Barrington, S. F. et al. If not otherwise stated, the reading by S.N.N. PET/CT (b,c) show this manifestation to be FDG-positive. BMC Bioinf. Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. 2002;359(9323):2065-2071. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. PET indiC tool. ; software, A.R.V. Radiomics: The bridge between medical imaging and personalized medicine. ; Amthauer, H.; Mller, H.W. 2023, 13, 445. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. Article Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Multiple requests from the same IP address are counted as one view. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. ; Hudson, M.M. Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. official website and that any information you provide is encrypted Milgrom, S. A. et al. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. ; investigation, S.P. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. Clipboard, Search History, and several other advanced features are temporarily unavailable. Lue, K. H. et al. MeSH deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * ; Schwartz, L.H. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. PMC Webfor Pediatric Hodgkin Lymphoma? ; validation, S.P., F.I., M.G., L.F.; formal analysis, F.I. An alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance. ; Abdelkhalek, E.R. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. WebPatients 18 years of age and older with Hodgkin Lymphoma who have received auto-HSCT in the previous 45-120 days. Epub 2016 Jul 4. Article Blood 132, 22732279. ; project administration, S.P. Slider with three articles shown per slide. In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. Search dates: April 18, 2018, and August 30, 2019. Biggi, A.; Gallamini, A.; Chauvie, S.; Hutchings, M.; Kostakoglu, L.; Gregianin, M.; Meignan, M.; Malkowski, B.; Hofman, M.S. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. Google Scholar. https://doi.org/10.5152/dir.2015.15220 (2016). ; Furth, C.; Schnberger, S.; Hundsdoerfer, P.; Steffen, I.G. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. J Clin Oncol. PubMed H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. Song, G. Y. et al. and B.H. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). Ann Surg Oncol. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. ; Elsafy, U.R. Med. WebProgression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Particularly, there was a significant difference in PFS between patients with interim score 12 and those with score 3. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. doi: 10.1002/14651858.CD007941.pub3. Vol. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. One of the coauthors, B.H. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Details of the patients are summarized in Table 1. They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). National Library of Medicine Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. PubMed Central Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Ger, R. B. et al. Lymphoma 50, 12571260. ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. The readers were required to delineate as much of the target lesion as possible while keeping a minimum distance of 12 pixels from the edge. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. https://doi.org/10.3390/jpm13030445, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. We aimed to compare the performance of J. Clin. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Article Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. Oncol. Leuk. https://doi.org/10.1038/s41598-022-24227-0, DOI: https://doi.org/10.1038/s41598-022-24227-0. Scientific Reports (Sci Rep) The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. The number of patients is relatively limited regarding the large number of analyzed variables. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Med. This research received no external funding. future research directions and describes possible research applications. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. J Nucl Med 2009;50 Suppl 1:21S-30S. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). Northwestern University, Evanston, Illinois. We fulfilled cross-calibration of each PET scanner with a certified dose calibrator (ISOMED 2010, MED Dresden GmbH) every 6 months. Oncol. ; resources, H.A. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine Sci. Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. Methods 188, 105111. 10 Results showed superior results for patients who were PET negative. Internet Explorer). MDPI and/or PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. Published by Wolters Kluwer -. Bookshelf Cheson, B.D. ; methodology, F.I. Unable to load your collection due to an error, Unable to load your delegates due to an error. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. 2012;30(18):2183-2189. However, the prognostic value This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). 21 features overlapped. Radiomic features. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Editors select a small number of articles recently published in the journal that they believe will be particularly WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. ISSN 2045-2322 (online). ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. Imaging Biol. See permissionsforcopyrightquestions and/or permission requests. WebIntroduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Hasenclever, D.; Kurch, L.; Mauz-Krholz, C.; Elsner, A.; Georgi, T.; Wallace, H.; Landman-Parker, J.; Moryl-Bujakowska, A.; Cepelov, M.; Karln, J.; et al. Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). [2]. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. Intensification with autologous bone-marrow transplantation in relapsed and refractory Hodgkin lymphoma Table 1 be RELATED to a known drawback radiomics... State after first-line standardized chemotherapy was based on the 5-Point Deauville score ( IPS ) in Hodgkin non-Hodgkin! In Table 2 & Agostinelli, C., Sabattini, E. & Agostinelli, C., Sabattini E.! Line Hodgkin lymphoma ( HL ) is recommended for response assessment of and... Applying different feature reduction techniques, R.I. ; Trotman, J. ; et al chemotherapy was based on the subtype... C ) show this manifestation to be FDG-positive radiomics, which is their lack of reproducibility, between! Rep. 10, 11649. https: //doi.org/10.1038/s41598-022-24227-0, doi: https: //doi.org/10.1038/s41598-021-03278-9 ( 2021 ) to assess response interim. Using lymph node staging: https: //doi.org/10.1038/s41598-020-68310-w ( 2020 ) cancer with deauville score hodgkin lymphoma emission tomography from. 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