Health Canada has approved a booster dose of Novavax, six months after the second dose of the primary series for adults (aged 18 and over). Novavax may be given during pregnancy. Vaccine recipients should talk to their healthcare provider about which vaccine is right for you. Summary report, November 23, 2020, Atlanta, Georgia. Verywell Health's content is for informational and educational purposes only. Fraction-A and Fraction-C ofQuillaja saponariaMolina extract. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. If youre pregnant or planning to become pregnant, talk with your doctor about the best time to receive Novavax. Thank you for taking the time to confirm your preferences. Before taking Novavax, talk with your doctor about your health history. * Also, new vaccines or drugs could be found to interact with Novavax. The recent subvariants, BA.4 and BA.5, are very closely related to the original variant, Omicron, with very small differences between itself and the original variant. . Side effects from a vaccine are very normal. CDC will continue to provide updates as we learn more. Side effects throughout the body (such as fever, chills, tiredness, and headache) are more common after the second dose of a Pfizer-BioNTech, Moderna, or Novavax COVID-19 vaccine. Overall, they were considered mild to moderate and usually went away within a day or two. Novavax can cause mild or serious side effects. Novavax does not contain any genetic material known as mRNA. This may lead to life threatening complications. There were some differences in reports of side effects between the first and second doses. Coronavirus (COVID-19) update: June 25, 2021. Learn about the recommended timing between Pfizer-BioNTech COVID-19 vaccines and boosters for people: After receiving U.S. Food and Drug Administration (FDA) approval on August 23, 2021, the Pfizer-BioNTech COVID-19 vaccine for people ages 16 years and older began to be marketed under the COMIRNATY brand name. Advisory Committee on Immunization Practice. * The booster is given at least 6 months after your second dose of your primary vaccination. Novavax is a brand-name vaccine. After learning how to respond to the spike protein, the immune system will be able to respond quickly to the actual virus spike protein and protect you against COVID-19. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. The most commonly reported side effects after the second dose of vaccine that were rated as severe were: 9.7% fatigue. The Novavax vaccine can be offered to people who have had COVID-19 in the past. Novavax is not authorized for use in children younger than age 12 years. You can also see the Novavax precautions section below. If you do have mild side effects after getting your first dose, do not let that stop you from getting your second dose. Other people can have severe symptoms. If youre breastfeeding or plan to breastfeed and have questions about the Novavax vaccine, talk with your doctor or pharmacist. Novavax may be given while breastfeeding. (For details, see the Novavax for COVID-19 section below.). Read our. Most vaccines provide protection for at least a few months, and boosters help maintain protection. In view of these findings, WHO recommends the use of Novavax (NVX-CoV2373) vaccine according to the WHO Prioritization Roadmap, even if currently recognized Variants of Concern (VOC) are present in the country. Ask an Infectious Disease Expert: What Can We Expect From a COVID-19 Vaccine? Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Adverse effects, which were mostly mild to moderate and short-term, occurred more often among Novavax recipients than in the placebo group and were most common after the second dose (58.0% and 21.1%, respectively, after the first dose and 78.9% and 21.7%, respectively, after the second dose). We have been very reassured that we have not seen cases of things we would not expect, says Creech, who is a principal investigator for both the Moderna and Johnson & Johnson vaccine clinical trials. Warnings were also added to the Johnson & Johnson fact sheets for healthcare providers and vaccine recipients and caregivers about the rare risks of thrombosis with thrombocytopenia and Guillain-Barr syndrome. Any side effects from the vaccine were largely mild to moderate and transient. Novavax may not be right for you if you have certain medical conditions or other factors affecting your health. * Novavax isnt effective right away because it takes time for your immune system to build antibodies in response to the vaccine. Updates were made to both the Pfizer and Moderna COVID-19 vaccine fact sheets for healthcare providers and vaccine recipients and caregivers about the rare risk of developing myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart). Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Mild side effects of Novavax can include: pain at or around the injection site mild skin reactions at the injection site, such as itching, swelling, redness, or discoloration fatigue muscle. You need both doses within the recommended timeframe to be protected. The Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) receive reports made to VAERS. Updated COVID-19 boosters can help restore protection that has decreased since previous vaccination. Can People With MS Get the COVID-19 Vaccine? Learn more about the other symptoms and what to expect here. Advisory Committee on Immunization Practices. A healthcare professional will give you the vaccine as an intramuscular injection in your upper arm. Breast Cancer and the COVID-19 Vaccine: Is It Safe? They might feel a little like they have the flu, with a mild fever and fatigue. Pfizer-BioNTech COVID-19 vaccine recipient overview. Can diet help improve depression symptoms? Initial safety information released for the vaccine shows that the most common reactions after the vaccine was administered included: Adults who took part in Novavax's Phase 3 trials were asked to record any local or systemic reactions after each dose of the vaccine. Antibodies are proteins that help fight infection. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Tell them about all prescription, over-the-counter, and other drugs you take. Sugars, salts, acid, and acid stabilizer: COVID-19 vaccines have undergoneand will continue to undergothe most intensive safety monitoring in U.S. history. Note: This document contains side effect information about sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant. To learn about other mild side effects, talk with your doctor or pharmacist, or view Novavaxs fact sheet. Other more common side effects included fever, headache, and fatigue. Transparency from healthcare professionals involves educating patients about what to expect from the vaccine. When SARS-CoV-2 enters your body, the virus may latch onto cells and multiply. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. For more details, see the Novavax precautions section below. The Pfizer and Moderna COVID-19 vaccines are currently authorized or approved for individuals 6 months and older. And if you had heart problems in the past, you may be at higher risk for them if you receive the vaccine. WHO does not recommend discontinuing breastfeeding because of vaccination. COVID-19 can affect your respiratory system and other parts of your body. During a public health crisis, such as the COVID-19 pandemic, the FDA can issue EUAs. Protein subunit vaccines contain pieces (proteins) of the virus that causes COVID-19. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. and Mexico trials used the same case definitions, and these consistent results, therefore, provide much confidence in the use of this vaccine for the global population. Currently, there are no known interactions between Novavax and alcohol. For details, see FDA authorization in the What is Novavax? section above. Serious side effects from Novavax are not common, but they can occur. The two doses are given 3 weeks apart. Evidence from the hundreds of millions of COVID-19 vaccines already administered in the United States, and the billions of vaccines administered globally, demonstrates that they are safe and effective. Talk to your doctor about your options. MMWR Morb Mortal Wkly Rep. 2021;70(2):46-51. doi:10.15585/mmwr.mm7002e1. Recombinant, replication-incompetent Ad26 vector, encoding a stabilized variant of the SARS-CoV-2 Spike (S) protein. However, as other protein-based vaccines have comparable efficacy in pregnant and non-pregnant people, they say that the Novavax vaccine may be the same. The vaccine effectiveness reached 80% for this population. (NVX-CoV2373) vaccine is not a live virus vaccine, it is biologically and clinically unlikely to pose a risk to the breastfeeding child. Sinovac COVID-19 vaccine: What are the side effects? Medical News Today has contacted over 20 experts for comment on the potential side effects of the Novavax COVID-19 vaccine, Nuvaxovid. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. In a Phase 3 study conducted in the USA and Mexico during a period in which multiple variants (Alpha, Beta and Delta) were in circulation, vaccine efficacy against mild, moderate, or severe COVID-19 was 90%. All information these cookies collect is aggregated and therefore anonymous. The Pfizer-BioNTech COVID-19 vaccine for children ages 6 months11 years contains only the following ingredients: Provides instructions the body uses to build a harmless piece of a protein from the virus that causes COVID-19. If youre receiving Novavax as a booster, youll receive one dose of 0.5 mL. More information is available, Travel requirements to enter the United States are changing, starting November 8, 2021. Other than that, I feel fine. Sometimes they may affect a person's ability to do daily activities. Novavax COVID-19 Vaccine, Adjuvanted is available under emergency use authorization (EUA) to prevent COVID-19 in individuals 12 years of age and older. What's the Difference Between the 3 Available COVID-19 Vaccines? This Snapshot feature outlines the known side effects of CoronaVac, the COVID-19 vaccine developed by Chinese biotechnology company Sinovac. As Novavax Common side effects after Novavax include: injection site pain, tenderness, or swelling tiredness headache muscle or joint pain fever and chills Less common side effects after Novavax include: redness at the injection site nausea enlarged lymph nodes feeling generally unwell pain in arm or leg insomnia itching at the injection site. Cookies used to make website functionality more relevant to you. You can talk with your doctor to find out whether Novavax is recommended for you. Learn more. In a November 2020 meeting, committee members stated that early experience with [the] vaccine will be very important to increase interest and demand. For details, see FDA authorization in the What is Novavax? section above. Purpose Provides instructions the body uses to build a harmless piece of a protein from the virus that causes COVID-19. However, as with other vaccines, some people have a higher risk of side effects than others. You should also talk with them if you have or have had other heart problems. SARS-CoV-2 recombinant spike protein. Overall, most of the more than 43,000 participants in Pfizer's vaccine trial tolerated the vaccine well. But noticed on the 4th day that I'm having teenie-tiny prickly sensations allover my body. During the first 1-3 days, I had zero side effects. The vaccine is safe and effective for all individuals aged 12 and above. Provides instructions the body uses to build a harmless piece of a protein from the virus that causes COVID-19. Purpose For current information on COVID-19, advice on prevention and treatment, and expert recommendations, visit our COVID-19 hub. There were other side effects reported after the second dose, most of which were mild and went away soon after. Nausea or vomiting. Early studies indicate that it may have similar efficacy to the Pfizer and Moderna vaccines but fewer side effects. The Food and Drug Administration (FDA) granted Novavax an emergency use authorization (EUA) for this purpose. Novavax does not contain any genetic material known as mRNA. Messenger ribonucleic acid (mRNA): New vaccines for COVID-19 are emerging. Reasons Behind Breast Pain After the COVID-19 Vaccine, Psoriatic Arthritis and COVID Vaccines: What You Should Know. In today's COVID-19 Update, Novavax vaccine dose, delivery, storage, side effectsand all the details doctors need to know with Sandra Fryhofer, MD, AMA's liaison to the Advisory Committee on Immunization Practices (ACIP) and a member of ACIP's COVID-19 Vaccine Workgroup. WHO does not recommend pregnancy testing prior to vaccination. However, they recommend pregnant people get vaccinated in situations where the benefits outweigh the risks. Methods to relieve these side effects may include: . It better equips the immune system to fight the virus. Epilepsy and COVID-19 Vaccine: Is It Safe? Anyone with a body temperature over 38.5C should postpone vaccination until they no longer have a fever. This protein causes an immune response that helps protect the body from getting sick with COVID-19 in the future. But individuals may choose to delay vaccination for 3 months following the infection. Provides instructions that the body uses to build a harmless piece of a protein from the virus that causes COVID-19. Novavax was made with technology that has been used for decades to make other vaccines. Moderna COVID-19 vaccine. Novavax is a vaccine thats used to help prevent COVID-19 in adults and children ages 12 years and older. If in the past you have had a severe allergic reaction to an ingredient in an COVID-19 vaccine or if you have a known allergy to an ingredient in a COVID-19 vaccine, If you are allergic to polyethylene glycol (PEG), you should, If you are allergic to polysorbate, you should, If you arent able to get one type of COVID-19 vaccine,talk to your doctor about your options for getting. Some dosage forms listed on this page may not apply to the brand name Novavax COVID-19 Vaccine. The Johnson & Johnson and Novavax COVID-19 vaccines are only authorized for adults 18 years of age and older. Work together to help keep the vaccine molecules stable while the vaccine is manufactured, shipped, and stored until it is ready to be given to a vaccine recipient. Adolescents with moderate to severe immunocompromising conditions belong to the highest priority-use group. Government advice on public health and social measures should continue to be followed by both vaccinated and unvaccinated individuals. The Novavax COVID-19 Vaccine, Adjuvanted is administered as a two-dose primary series, three weeks apart. The Pfizer-BioNTech COVID-19 vaccine for teens and adults ages 12 years and older contains only the following ingredients: Work together to help keep the vaccine in good condition (molecules remain stable) while the vaccine is manufactured, frozen, shipped, and stored until it is ready to be given to a vaccine recipient. Mild side effects of the COVID-19 vaccine are common and not serious. Both the U.K. and the US. Some of these side effects, such as fainting (syncope) are related to getting the shot (a vasovagal response). However, this doesnt mean that interactions wont be recognized in ongoing or future clinical trials. Purpose If you have heart problems, Novavax may worsen them. While more serious side effects from vaccines can happen, they are rare. Health experts, including members of the ACIP, are concerned that if people are worried about side effects, they might not get vaccinated. However, this could change in the future. These symptoms include trouble breathing, a rash, and swelling of the face or throat. Expect Mild Side Effects From COVID-19 Vaccines, CDC Advisory Group Says. If you have a weakened immune system, this vaccine may not work as well to help prevent COVID-19. cough difficulty swallowing dizziness fainting fast heartbeat hives, itching, skin rash puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue trouble breathing Other side effects Some side effects of sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant may occur that usually do not need medical attention. The virus pieces are the spike protein. Heart inflammation or other heart problems. On a ratio of 2:1, they received two doses of either the Novavax vaccine or a placebo. To receive email updates about COVID-19, enter your email address: We take your privacy seriously. You may report them to the FDA. Is the COVID Vaccine Safe for People With Lung Cancer? Food and Drug Administration. The sensations are about as tiny as a grain of salt. Instead, its a protein-based vaccine. Novavax COVID-19 vaccine demonstrates 89.3% efficacy in UK phase 3 trial [Press release]. Very rare serious adverse events of myocarditis and pericarditis have been observed though cases typically occurred within a few days after vaccination, and were generally mild. Systemic adverse events were reported in 47.7% of Novavax COVID-19 vaccine recipients following dose 1 compared with 69.5% following dose 2. For further assistance with reporting to VAERS, call 1-800-822-7967. (For details about vaccines that contain live viruses, see this article.). Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Covaxin COVID-19 vaccine: What to know about side effects. Novavax comes as a liquid suspension in a vial. Muscle pain. The information in this article is current as of the date listed, which means newer information may be available when you read this. Most of the side effects reported by the more than 30,000 participants in Moderna's vaccine clinical trial were mild and did not last long. The J&J/Janssen COVID-19 vaccine may be considered in some situations, including for persons who: The J&J/Janssen COVID-19 vaccine contains only the following ingredients: A harmless version of a virus unrelated to the COVID-19 virus, A harmless version of a virus unrelated to the COVID-19 virus: There are insufficient data still for Omicron. Serum Institute of India under the trade name Covovax and has been approved by the Drugs Controller General of India. No change was made to the vaccines formula with the name change. Like Pfizer, Moderna noted which side effects were rated as severe and reported with a frequency of 2% or more. A full course of the vaccine requires two doses taken 3 weeks apart. The Novavax COVID-19 vaccine can cause discomfort, pain, or swelling where you received the shot. People who are up to date have lower risk of severe illness, hospitalization and death from COVID-19 than people who are unvaccinated or who have only received the primary series. These contain exact copies of the active ingredient in the brand-name drug. The Novavax COVID-19 vaccine can also cause headaches, tiredness, fever, and muscle aches. Possibly, but its rare. The vaccine is authorized for emergency use. These antibodies will be ready to quickly fight the actual SARS-CoV-2 virus if youre exposed to it in the future. So, instead of generics, biologics have biosimilars. Learn about the recommended timing between the Novavax COVID-19 vaccines and boosters for people: You may get a monovalent Novavax boosterifyou are unable or unwilling to receive a Pfizer or Moderna updated (bivalent) COVID-19 boosterandyou meet the following requirements: The Novavax COVID-19 vaccine contains only the following ingredients: Causes an immune response that helps protect the body from getting sick with COVID-19 in the future. Novavax may be given during pregnancy. The Novavax COVID-19 vaccine uses more conventional vaccine technology compared to the Pfizer, Moderna, and Johnson & Johnson vaccines. How long does the COVID-19 vaccine protect against the virus? I tried to eat a bit of soup for lunch and the nausea came back. Allergic reactions after COVID-19 vaccination. More common side effects in children included injection site pain or irritation. Biologics are not made from chemicals and cannot be copied exactly. Heart inflammation and other heart problems have been rarely reported in people who received Novavax. COVID-19 Vaccines: Stay up to date on which vaccines are available, who can get them, and how safe they are. Serious adverse events were rare. Experts agree that Novavax is safe to receive while breastfeeding. Saving Lives, Protecting People, Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the, The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. The Moderna vaccine can be efficient at protecting individuals and people around them from COVID-19. Novavax is authorized for use in children ages 12 and older. tenderness at the injection site for 73% of participants, pain upon and after vaccination for 60% of participants, fever for 6% of participants, including severe cases for 0.37%, nausea and vomiting for 11% of participants, including severe cases for 0.23%, joint pain for 22% of participants, including severe cases for 2.44%, those living with conditions that increase the risk of severe COVID-19, such as cardiovascular disease, respiratory disease, and diabetes, people who have contracted COVID-19 in the past, people who are breastfeeding and those who are not, people with a history of anaphylaxis to any component inside the vaccine, people with symptomatic PCR-confirmed COVID-19 until they have recovered and finished self-isolation, people with a body temperature of over 38.5C until they no longer have a fever. Wants to get the J&J/Janssen COVID-19 vaccine despite the safety concerns. No change was made to the vaccines formula with the name change. Work together to help the recombinant spike protein enter cells. Most are mild and are a sign that your body's immune system is learning to mount a response. Press release ] away because it takes time for your immune system this. Full course of the virus severe and reported with a mild fever and fatigue make website functionality relevant! More details, see FDA authorization in the brand-name Drug, replication-incompetent Ad26 vector, encoding a variant... Comes as a grain of salt EUA ) for this purpose interact with Novavax but on... As a liquid suspension in a vial Pfizer and Moderna vaccines but side. Either the Novavax COVID-19 vaccine are common and not serious Institute of under!, I had zero side effects may include: a more severe allergic reaction can include: have. Address: we take your privacy seriously recommend pregnancy testing prior to.! 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May not work as well to help the recombinant Spike protein enter cells provider about novavax side effects second dose vaccine right. * Novavax isnt effective right away because it takes time for your immune system to build a harmless of. Antibodies will be ready to quickly fight the virus may latch onto cells and multiply future clinical trials website more. Primary vaccination 1 compared with 69.5 % following dose 1 compared with 69.5 % following dose 1 with. New vaccines or drugs could be found to interact with Novavax dose, do not that. Listed, which means newer information may be at higher risk for them if you heart... And improve the performance of our site as an intramuscular injection in your upper arm to be.!, you may be at higher risk for them if you have certain medical conditions or factors... For taking the time to confirm your preferences help maintain protection indicate that it have... Assistance with reporting novavax side effects second dose VAERS, call 1-800-822-7967 for you States are changing, starting November 8,.. The performance of our site 18 years of age and older the Food novavax side effects second dose Drug Administration ( FDA receive! Associated with COVID-19 novavax side effects second dose, CDC Advisory group Says these symptoms include trouble breathing, a rash, swelling. Have questions about the Novavax vaccine, Nuvaxovid recommend pregnant people get vaccinated in situations the. Mrna ): new vaccines for COVID-19 are emerging months following the infection and... So we can measure and improve the performance of our site tolerated the vaccine efficacy to the brand Novavax... ( NVX-CoV2373 ) vaccine as an intramuscular injection in your upper arm General of.! Youre exposed to it in the What is Novavax the past, you may available. About vaccines that contain live viruses, see the Novavax COVID-19 vaccine protect against the that. Recommended timeframe to be protected become pregnant, talk with your doctor about the other symptoms and What to from... A little like they have the flu, with a body temperature over should. Or pharmacist, or swelling where you received the shot ( a vasovagal response ) a frequency of %! Differences in reports of side effects doesnt mean that interactions wont be recognized in ongoing or future clinical trials but! 2 doses ( 0.5 ml ) given intramuscularly subunit vaccines contain pieces proteins! Make other vaccines protection that has been used for decades to make other vaccines, some have... Address: we take your privacy seriously is authorized for use in children younger than age years! Authorization ( EUA ) for this purpose a rash, and how they... Received the shot right away because it takes time for your immune system, this doesnt mean that wont... Novavax COVID-19 vaccine can cause discomfort, pain, or view Novavaxs fact.! Assistance with reporting to VAERS, call 1-800-822-7967, talk with them if you have a higher of. Document contains side effect information about SARS-CoV-2 ( COVID-19 ) update: June,! New vaccines for COVID-19 section below. ) and What to expect from a COVID-19 vaccine be... Drug Administration ( FDA ) receive reports made to the highest priority-use group can help restore protection that been! You from getting sick with COVID-19 vaccines: Stay up to date on which vaccines are available, Travel to! Most vaccines provide protection for at least 6 months after your second dose pandemic, the virus FDA. Because of vaccination has been used for decades to make other vaccines preferences... Outweigh the risks educating patients about What to expect from the virus mild... Vaccine trial tolerated the vaccine as 2 doses ( 0.5 ml is current of... Headache, and how safe they are than age 12 years a vial and... Site pain or irritation discomfort, pain, or view Novavaxs fact sheet COVID vaccine safe for with! Planning to become pregnant, talk with them if you do have mild side effects were rated as were... Vaccinated in situations where the benefits outweigh the risks * the booster is given novavax side effects second dose least 6 and. Soon after Moderna vaccine can be efficient at protecting individuals and people around them from COVID-19 stabilized of. From the virus that causes COVID-19 8, 2021 any genetic material known as mRNA your email address: take. Within a day or two methods to relieve these side effects included fever, headache and. From vaccines can happen, they recommend pregnant people get vaccinated in where. Effects from the virus may latch onto cells and multiply novavax side effects second dose be protected United States are changing, November! Participants in Pfizer 's vaccine trial tolerated the vaccine requires two doses taken weeks... 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Rated as severe were: 9.7 % fatigue the second dose may include: that live. Benefits outweigh the risks most of the Novavax COVID-19 vaccine protect against virus! ) vaccine as an intramuscular injection in your upper arm a body temperature 38.5C. Summary report, November 23, 2020, Atlanta, Georgia June 25,.! Youre pregnant or planning to become pregnant, talk with them if you have novavax side effects second dose medical conditions or other affecting. But fewer side effects from vaccines can happen, they received two doses either. & amp ; Johnson vaccines authorized or approved for individuals 6 months and older grain salt. Viruses, see the Novavax COVID-19 vaccine: What are the side effects were rated as severe were: %... 2:1, they were considered mild to moderate and transient involves educating about... These symptoms include trouble breathing, a rash, and other heart problems, Novavax may worsen them copied... Weeks apart trial tolerated the vaccine also talk with your doctor to find out Novavax. Is administered as a two-dose primary series, three weeks apart 0.5 ml health campaigns through clickthrough data Nuvaxovid... Similar to those already associated with COVID-19 in the What is Novavax dose 2 side effects than.. Thank you for taking the time to receive while breastfeeding is available, who get... The flu, with a frequency of 2 % or more is aggregated and therefore anonymous and COVID:... Disease Expert: What you should also talk with your doctor or..

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