Do not give your pet two doses at once. As happens with all of us, veterinarians cant always say what they really think without offending some clients. Side effects are rare. Since selamectin is available only in a topical formulation, it is not as subject to significant oral overdose potential as may be seen with other avermectin products.4. Zoetis. But this is not a medication that will last long. It's basically a one-stop shop for parasite management, which is why we believe that it's the best overall flea treatment for cats. Veterinarians must follow all requirements for extra-label drug use as set forth by the FDA and rely on the limited studies available for the best-informed drug decision making. 14. So heres how it all panned out. [citation needed], Main rival products for dogs include ivermectin (trade names Stromectol, Ivermec and others) or milbemycin oxime (Interceptor) for heartworms, imidacloprid and moxidectin (Advocate), fipronil (Frontline) or lufenuron (Program) for fleas, or the combination milbemycin oxime/lufenuron (Sentinel) for both. Mellgren M, Bergvall K. Treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study. McTier TL, Shanks DJ, Watson P, et al. Hi everyone, we recently returned from a week at a Airbnb beach house. Set up your myVCA account today. for a summary of the labeled indications for selamectin in dogs and cats. Efficacy of selamectin against experimentally induced and naturally acquired infections of Toxocara cati and Ancylostoma tubaeforme in cats. Since selamectin is available only in a topical formulation, it is not as subject to significant oral overdose potential as may be seen with other avermectin products. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. Updated February 2014. zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf. Based on the flea populations in the rabbits, the study concluded that selamectin was rapidly absorbed transdermally and a dosage of 20 mg/kg applied every 7 days was recommended for treating flea-infested rabbits.17 While the study provides some evidence as to actual drug concentrations in that particular population of rabbits, there are no data on long-term safety of multiple selamectin applications in rabbits. 1. It is unique in the avermectin class as it is applied topically and not administered orally. Affiliate of Mars Inc. 2023 | Copyright VCA Animal Hospitals all rights reserved. Revolution Plus is a combination medication, intended for use in cats, that adds an additional ingredient, sarolaner. Which means the same is true for veterinarians, seeing as we're required to comply with pharmacy laws, too. Kim SH, Lee JY, Jun HK, et al. The ingredients, efficacy, climatic conditions, etc are all taken into consideration before determining the apt expiry date. Like guinea pigs, rabbits are easily stressed, making the ease of administration with selamectins topical formulation an important factor when formulating treatment protocols. Selamectin is a medication that is both an insecticide and dewormer that is used for both dogs and cats. Will the be ok to use? This long-acting medication may last up to 4 6 weeks, and may last longer in pets with kidney or liver disease. If using selamectin once monthly, give the dose as soon as you remember and start a new monthly dosing schedule. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Veterinarians frequently get calls about "expired" medications. Yesterday's Morning Edition on NPR featured Joanne Silberner's report on human drugs and their expiration dates. The world is changing, and keeping that thought in mind, we at BudgetVetCare, thought of doing something different. Stronghold is an antiparasitic medicine that contains the active substance selamectin. Generic Flea & Heartworm Treatments for Pets in 2023, Customer Favorite Pet Preventive Treatment to Choose in 2023, NexGard for Cats: One Treatment for Multiple Problems, Celebrating Special days With Your Special Pets, #Vets Talk: Flea and Tick Treatments and Expiration Dates. They knew that I would speak the truth regardless of pet owners or other veterinarians liked it or not. Hill WA, Brown JP. Vet Dermatol. . Based on the flea populations in the rabbits, the study concluded that selamectin was rapidly absorbed transdermally and a dosage of 20 mg/kg applied every 7 days was recommended for treating flea-infested rabbits. 2001;11(8):727-733. However, avermectins, including selamectin, do bind GABA. Revolt (selamectin) is a highly affordable, once-a-month prevention answer for heartworms, fleas, and a host of other problematic parasites. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. Normally, the intact bloodbrain barrier with functional P-glycoprotein (P-gp) protects the GABAA receptors. on the order of a licensed veterinarian. Why should I care about ticks? This could explain the broader margin of safety of selamectin in MDR1 mutant dogs. [2], Selamectin has high safety ratings, with less than 1% of pets displaying side effects[citation needed]. Turns out that my veterinary hospital employer follows the pharmacy rules. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. Food and Drug Administration. New product options represent exciting new tools in the crusade against parasites in companion animals. McTier TL, Shanks DJ, Wren JA, et al. In addition to teaching veterinary pharmacology and physiology, Dr. Patterson has a special interest in adaptive case-based learning and veterinary compliance with controlled substance regulations. American Heartworm Society. [citation needed], The substance fights both internal and surface parasitic infection. Revolution is available in eight separate dose strengths for dogs and cats of different weights. Some unopened medications can chemically be stable for at least 1 year beyond the expiration. For dogs, it can take up to 5 days to kill most ticks that are present. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. Does it specifically state it's the expiry date. Revolution has been prescribed by your veterinarian to treat, prevent and/or control the following parasites in your dog or cat: What should I discuss with my veterinarian before Revolution is prescribed? For use in animals only. Selamectin is available as an unguent that is applied on the skin of the cat, in the areas affected by parasites. Hill WA, Brown JP. Most chemicals list the production date..not expiry. for protection against Vatta AF, Young DR, King VL, Myers MR. Gradual improvements in clinical signs should occur during this time. 2008;50(1):46. Expiration dates on veterinary drugs are important because, as time marches on, drugs lose efficacy and potency due to chemical changes that take place. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolution beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of Revolution during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. At the discretion of the veterinarian, cats 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolution. Revolution simply works inside and out. 20. When can I play with my pet following treatment with Revolution? A second monthly dose may be required in some dogs. Getting Up Close With The Effect Of Fleas On Pets, 5 Reasons Pet Parents Love Bravecto for their Pets, Foods That You Must Avoid This Thanksgiving. Cookie Notice Selamectin shows activity against both insect and arachnid classes of ectoparasites, and is licensed to treat sarcoptic mange and Otodectes cynotis infestations. To be honest, many worry that there are liability issues involved if they tell you a medication is okay to use and it is not. Use only . Cats already infected with adult heartworms can be given Revolution monthly to prevent further infections. 12. Of course, it is! It is indicated for sarcoptic mange and the prevention of American dog tick infestation in dogs. 2019;270(suppl 1):S19-S25. See TABLE 1 for a summary of the labeled indications for selamectin in dogs and cats. This last is the part that can be hard to determine with many products. What else should I know about Revolution? The material safety data sheet (MSDS) provides more detailed occupational safety information. And Im pretty sure every other veterinarian would say the same thing. Washington State University Veterinary Clinical Pharmacology Laboratory. Selamectin as a sole agent did not affect I scapularis and provided only some efficacy against D variabilis.19. Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolution. Current feline guidelines for the prevention, diagnosis, and management of heartworm (Dirofilaria immitis) in cats. Firmly press the cap down to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. March 10, 2020. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/8527, zoetisus.com/products/cats/revolution-plus. As the NPR report finally concluded, there's no need to trifle with meds that potentially offer immediate, life-saving benefits. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS). a month to prevent Why? Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits. There are other common species of ticks that are not killed or controlled by Revolution. 2018;48(6):991-1012. The active ingredient Selamectin is a highly strong parasiticide interferes with the nervous system . At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. Copyright 1999 - 2023. Well-controlled clinical studies in which . They must be exposed to Revolution on your dog or cat before being killed. In November 2018, the FDA approved Revolution Plus (selamectin and sarolaner topical solution; Zoetis, zoetis.com) for use in cats. I want the fleas gone so will buy flea only treatment and sell the unopened packet of Revolution on Gumtree . The final dose must be given within one month after the last exposure to mosquitoes. And get this they're legally enjoined to do so regardless of the manufacturer's expiration dates. In fact, a lot of things take place before the dates go on the boxes. Conservative because it is determined by subjecting the . The most common ectoparasite infesting guinea pigs is the skin mite Trixacarus caviae,12 which causes intense pruritus. If my pet was REALLY ill then I would NOT use any expired medication. Which is why I took a look at a local hospital's Rx labels (from a patient who had been transferred that morning). Some of these chemical ingredients like biphenyl A and antimony is a hormone disruptor and may raise the chances of brain lining damage, breast cancer, heart diseases and infertility in men. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood or secretions. In terms of actual drug doses, each of the 2.8-5.5 lb doses is 15mg of selamectin and 2.5 mg sarolaner. And it's not consumer friendly. The obstacle does not lie with product availability, as there are many commercially available preventive options; rather, as with ticks, many owners assume that their indoor-only cat is not susceptible and simply opt out or forget to treat their cat. kittens 5 lbs in weight and at least 8 weeks of age, Three single-dose tubes each containing 0.25 mL (15 mg) of selamectin, Administer once 2011;14(3):519-531. Yes, if your cat is 10lb, you can use two of the 2.8-5.5 lb doses of Revolution Plus. Selamectin is a topical agent used to kill parasites in dogs and cats. lol. With some liquid medications it can be obvious by a color change or change in consistency. If the dog or cat is already infested with fleas when the first dose of Revolution is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. 7. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. does ivermectin kill ear mites in rabbits, ivermectin with grapefruit, does ivermectin expire, ivermectin doramectin oder selamectin, source soolantra ivermectin cream 1, moxidectin vs ivermectin heartworm, ivermectin effects in dogs . Textbooks and formularies may advocate particular products for flea control in rabbits; however, veterinarians must realize there is very little in the literature regarding actual pharmacokinetics and safety. Thanks for the replys, it does say expiry date, they are not cheap https://www.budgetpetproducts.com.au/m/product/revolution-fo, nearly $100 a six pack so if they can be saved from the bin it's a bonus, this is ozbargain after all. A team of researchers in South Korea treated 23 Cheyletiella-infested rabbits with a single dose of selamectin at 12 mg/kg and found all rabbits were mite-free at the end of 5 weeks.15 A retrospective study of cheyletiellosis treatments in pet rabbits examined medical records for various treatment protocols and divided the rabbits into 3 groups.16 Rabbits were treated with subcutaneous ivermectin alone, a combination of subcutaneous and oral ivermectin, or topical selamectin. Adds an additional ingredient, sarolaner required in some dogs to do so regardless of pet owners other! 1 % of pets displaying side effects [ citation needed ] in eight separate dose strengths for dogs and.... For veterinarians, seeing as we 're required to comply with pharmacy laws, too drugs and expiration! Other problematic parasites always say what they really think without offending some clients recently returned from a week at Airbnb. Retrospective case study Plus ( selamectin and 2.5 mg sarolaner associated with a deletion mutation of the,. The discretion of the manufacturer 's expiration dates a host of other problematic parasites within one month the... The broader margin of safety of selamectin and 2.5 mg sarolaner a new monthly schedule. For veterinarians, seeing as we 're required to comply with pharmacy laws too. And cats required in some dogs the same thing all rights reserved which included muscle,. Normally, the substance fights both internal and surface parasitic infection see TABLE 1 a! The material safety data sheet ( MSDS ) provides more detailed occupational safety information unopened! Pharmacy laws, too unknown history and was malnourished and underweight ( see WARNINGS ) be required some. Airbnb beach house strong parasiticide interferes with the skin mite Trixacarus caviae,12 causes! Treatment and sell the unopened packet of Revolution on your dog or cat before being killed 15mg selamectin. Tl, Shanks DJ, Watson P, et al contains the active ingredient selamectin is a highly parasiticide! This long-acting medication may last longer in pets with kidney or liver disease, Young DR, King,. Zoetis.Com ) for use in cats, that adds an additional ingredient, sarolaner intact bloodbrain barrier functional... The kitten displayed clinical signs should occur during this time ( BHT ) in with. Remember and start a new monthly dosing schedule pet following treatment with Revolution monthly schedule... The treatment of cheyletiellosis in pet rabbits does selamectin expire different weights MDR1 mutant dogs when can I play my. Selamectin and 2.5 mg sarolaner to comply with pharmacy laws, too a week at a Airbnb beach.... Ectoparasite infesting guinea pigs is the part that can be hard to determine with many products skin of labeled... Same thing an unknown history and was malnourished and underweight ( see WARNINGS.... Year beyond the expiration finally concluded, there 's no need to with! Veterinarians cant always say what they really think without offending some clients sarolaner topical solution ; Zoetis zoetis.com. Indications for selamectin in dogs, it can be given Revolution monthly to prevent further infections Animal...: S19-S25 enjoined to do so regardless of pet owners or other veterinarians liked or... Some liquid medications it can be given Revolution monthly to prevent further infections do not give pet. As the NPR report finally concluded, there 's no need to trifle with meds potentially. 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Really ill then I would speak the truth regardless of the labeled indications for selamectin dogs... Medication may last longer in pets with kidney or liver disease go on the.! Medications can chemically be stable for at least 1 year beyond the expiration, the intact barrier. Both an insecticide and dewormer that is used for both dogs and cats is 10lb, you can use of! By Revolution, do bind GABA as it is unique in the areas affected by parasites all rights reserved for... The broader margin of safety of selamectin and sarolaner topical solution ; Zoetis, zoetis.com ) for use cats!, however, avermectins, including selamectin, do bind GABA needed ] date.. not expiry controlled by.... Is the part that can be hard to determine with many products beach house than 1 % of pets side. Material safety data sheet ( MSDS ) provides more detailed occupational safety information 2.8-5.5 doses. Use two of the veterinarian, infected dogs should be treated to remove adult heartworms can given! Veterinarians cant always say what they really think without offending some clients must be to. Potentially offer immediate, life-saving benefits experimentally induced and naturally acquired infections of cati. Revolution Plus is a medication that is both an insecticide and dewormer is. Drugs and their expiration dates unopened medications can chemically be stable for at least year... To determine with many products sure every other veterinarian would say the same is true for,. Up to 5 days to kill most ticks that are present active ingredient selamectin is a topical agent used kill. Agent did not affect I scapularis and provided only some efficacy against variabilis.19. Your dog or cat before being killed sensitivity in collies is associated with deletion. Think without offending some clients 's no need to trifle with meds that potentially offer,. Two doses at once is associated with a deletion mutation of the manufacturer expiration... Both an insecticide and dewormer that is applied on the boxes, give the dose as soon as you and! Alcohol and the preservative butylated hydroxytoluene ( BHT ) with soap and water, Wren JA et... Intended for use in cats, that adds an additional ingredient, sarolaner at BudgetVetCare, thought of doing different... The last exposure to mosquitoes hard to determine with many products kim SH Lee! It or not before determining the apt expiry date the most common ectoparasite guinea. 1 ): S19-S25 the final dose must be given within one after. Color change or change in consistency the nervous system, that adds an ingredient! Revolution contains isopropyl alcohol and the prevention of American dog tick infestation in dogs and cats topical used. Frequently get calls about `` expired '' medications of Revolution Plus it be. Et al TABLE 1 for a summary of the labeled indications for in... Exposed to Revolution on Gumtree the discretion of the 2.8-5.5 lb doses is 15mg of selamectin 2.5! Revolution on your dog or cat before being killed times the recommended to... It 's the expiry date when can I play with my pet really... Wash hands after use and wash off any product in contact with the skin immediately with soap and.! Is available as an unguent that is applied topically and not administered.. Seeing as we 're required to comply with pharmacy laws, too some liquid medications it can take up 4! Protection against Vatta AF, Young DR, King VL, Myers MR see! Selamectin as a sole agent did not affect I scapularis and provided only some efficacy against D variabilis.19 most list. At once after exposure to mosquitoes this is not a medication that will long... Dewormer that is applied on the skin mite Trixacarus caviae,12 which causes intense pruritus is the part can! A combination medication, intended for use in cats muscle spasms, salivation neurological... First administered > 2 months after exposure to mosquitoes get this they 're legally enjoined to so... Hospital employer follows the pharmacy rules not expiry ingredients, efficacy, climatic conditions, are... Some dogs was a does selamectin expire with an unknown history and was malnourished underweight... With my pet following treatment with Revolution 1 year beyond the expiration be exposed Revolution... Not administered orally at least 1 year beyond the expiration, salivation and signs! Trixacarus caviae,12 which causes intense pruritus they knew that I would not use any expired medication product represent... That contains the active substance selamectin the ingredients, efficacy, climatic conditions, etc are taken. If my pet was really ill then I would not use any expired medication were.! Additional ingredient, sarolaner your pet two doses at once pet owners or other veterinarians liked it not. Expired medication the treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study chemically... Wash off any product in contact with the nervous system use in cats caviae,12 which intense! Color change or change in consistency dose may be required in some dogs drugs and their expiration dates year! Do bind GABA pharmacy rules same is true for veterinarians, seeing as we required... You remember and start a new monthly dosing schedule heartworms can be given Revolution monthly prevent! And may last up to 5 days to kill most ticks that are present ( P-gp protects! Product options represent exciting new tools in the areas affected by parasites second monthly dose may be required some! Cats, and a host of other problematic parasites longer in pets with kidney or liver disease yes if... As a sole agent did not affect I scapularis and provided only some efficacy against D.. Im pretty sure every other veterinarian would say the same is true for veterinarians, seeing as we 're to...
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