The following information describes dosages that are commonly used or recommended. These drugs include insulin and other medications that increase insulin levels in the body. 1. Mayo Clinic does not endorse companies or products. A variety of factors, from diet to drugs to disease, can cause changes in the color and foaminess of your urine. Serious side effects from Jardiance arent common, but they can occur. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. However, since clinical studies ended, ketoacidosis has been reported in some people taking Jardiance. This kind of foam should also clear up quickly. People feel different symptoms with low blood sugar. It should only be used according to your doctors prescription. Triggers include a high carbohydrate, People with diabetes benefit from strategically balancing their diets. Metabolism occurs via glucuronidation. No. Now Streaming: 8 Questions You've Always Wanted to Ask About Your Pee. There is a problem with Below is a list of 10 Jardiance side effects you should be aware of. This helps to reduce the risk of ketoacidosis. Does How Often You Pee Say Something About Your Health? https://www.kidney.org/atoz/content/proteinuriawyska. It should be taken in the morning with or without food. For instance, lower abdominal pain and pelvic pain can be caused by urinary tract infections. In: Campbell-Walsh-Wein Urology. Jardiance and Farxiga are both brand-name drugs. However, taking Jardiance with certain diabetes drugs can increase your risk for hypoglycemia (low blood sugar). reduce the risk of cardiovascular death in adults with type 2 diabetes who also have known cardiovascular disease. These were toe amputations. Jardiance tablets should be stored at room temperature. Your doctor may adjust the dosage of Jardiance or your other diabetes medications to reduce the risk of hypoglycemia. improve glycemic control, as an adjunct to diet and exercise in adults with type 2 diabetes, reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease, and, reduce the risk of hospitalization and cardiovascular death in adults with heart failure and reduced ejection fraction. And sometimes, the problem is actually just your toilet. In studies, Jardiance and similar drugs increased the risk of ketoacidosis. Jardiance lowers blood sugar levels by causing the kidneys to get rid of excess sugar in the blood. People who have type 2 diabetes are usually resistant to insulin. Drinking enough water and fresh juices help flush out the microorganisms. rybelsus and jardiance together. For high blood pressure, youll also want to watch your diet and stay active. Serious side effects and their symptoms can include the following: Other serious side effects, explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Since the clinical trials took place, skin rash and itchiness have been reported in people using Jardiance. This weight loss was seen over 24 weeks of treatment. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. You can find useful tips on medication disposal here. However, increased urination can also cause dehydration (low bodily fluids) and low blood pressure. Usually, this symptom appears late in kidney disease, so immediate treatment is important. When bacteria enter the bladder, symptoms like burning while urinating, frequency and urgency, blood in your urine, or foam may appear. Its color and consistency depend on a variety of factors. Talk with your doctor about your risk of developing pancreatitis while taking Jardiance. If it continues, it could be a sign that you have kidney damage. In this study, people took Jardiance in combination with other treatments for diabetes and heart disease. However, separate studies of Jardiance and Farxiga have found them both to be effective at lowering blood sugar levels in people with type 2 diabetes and at reducing cardiovascular risks. How will I know if I have protein in my urine? Normally, the body releases a hormone called insulin when you eat food. In addition to the information below, you can refer to this detailed comparison of Jardiance vs. Farxiga. urinating more often than usual or making more urine than usual. In fact, in several clinical studies, Jardiance was taken in combination with metformin. If your urine is concentrated, drinking more water and other fluids will relieve dehydration and stop the foaming. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. You can learn more about how we ensure our content is accurate and current by reading our. In this condition, the kidneys do not function as they should and release protein into the urine. This list does not contain all drugs that may interact with Jardiance. In this article, we describe some of the best foods to eat and which types to, Nuts can help improve the outlook for people with diabetes. bloody or cloudy urine change in the color, amount, or odor of vaginal discharge difficult, burning, or painful urination frequent urge to urinate itching, stinging, or redness of the vaginal area lower back or side pain pain during sexual intercourse Less common. However, animal studies dont always predict what might happen in humans. During clinical studies, people taking Jardiance did not have an increased risk of ketoacidosis. Taking Jardiance and alcohol together can increase the risk of dehydration (low bodily fluids) and low blood pressure. Its available in two strengths: 10 milligrams (mg) and 25 mg. rybelsus and jardiance together. Do not take two doses at the same time. You may report side effects to the FDA at 1-800-FDA-1088. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Jardiance. information submitted for this request. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. (n.d.). (2018). These drugs have not been directly compared to each other in clinical studies. As with all medications, the cost of Jardiance can vary. Urine can appear foamy due to toilet cleaning chemicals. Foamy urine in the morning may be normal, or it may be a sign of a serious health issue. Below are examples of other drugs that are used to treat type 2 diabetes. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Jardiance lowers the risk of a heart-related death (like a stroke . In clinical studies, around 2.4 percent of people who took Jardiance had joint pain. Theyll ultimately prescribe the smallest dosage that provides the desired effect. Your healthcare provider may do blood tests to check how well your kidneys are working before and during your treatment with JARDIANCE. The pain typically occurs on the sides of the middle of your back, where your kidneys are located. Jardiance may not be right for you if you have certain medical conditions. One urine test, taken over a 24-hour period, compares albumin levels to levels of creatinine, which is a substance produced when muscles break down. Metformin is available as a generic drug and several brand-name drugs. They work in the same way to treat type 2 diabetes. vaginal or penile yeast infection *. You may opt-out of email communications at any time by clicking on When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. It can cause side effects that range from mild to. So, your doctor can prescribe a drug however they think it is best for your care. information highlighted below and resubmit the form. Before taking Jardiance, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Some toilet cleaning chemicals can make your urine look foamy. This can lead to dehydration (low bodily fluids) and low blood pressure. Also, you may need to stop using this medicine at least 3 days before having a surgery or medical tests. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This helps lower your blood sugar levels. Symptoms can include: feeling dizzy or falling when standing up, Serious urinary tract infections (including urosepsis and pyelonephritis), swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, pain, redness or discoloration, or swelling near the genitals or rectum, metformin (Glucophage, Glumetza, Fortamet, Riomet), hydrochlorothiazide (Esidrix, Hydrodiuril), premixed insulins (Humalog 50/50, Novolin 70/30), cardiovascular death (death caused by heart or blood vessel disease) in adults with both type 2 diabetes and, hospitalization and cardiovascular death in adults who have. Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage thats right for you. Partin AW, et al., eds. Increased amounts of protein in urine could mean you have a serious kidney problem. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This benefit was seen in people with and without a history of heart failure. However, elderly patients are more likely to have unwanted effects (eg, kidney problems, low blood pressure, or urinary tract infections), which may require caution in patients receiving this medicine. reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure . Damaged kidneys can allow too much protein to leak into your urine. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Dehydration takes place when your body loses more fluid than you drink. Call your doctor if you have any UTI symptoms. Ask your doctor if you have any questions. It is typically a sign of kidney disease but can occur with other medical conditions. If your urine is foamy, look for other symptoms as well. May make these conditions worse. Dizziness, lightheadedness, or fainting may occur with this medicine. If urine becomes highly concentrated a high level of waste products with little water your urine may have a strong ammonia odor. In animal studies, when pregnant animals were given Jardiance during those trimesters, kidney damage was seen in fetuses. The symptoms that you can check for include: Sometimes there might be blood and pus in your urine which may be the result of a urinary tract infection (UTI). Urine can foam up briefly every once in a while. Your doctor might prescribe Jardiance by itself or for use with other medications. When you start JARDIANCE, you may experience increased urination. In a clinical study, around 3 percent of people had increased urination as a side effect of Jardiance. Ketoacidosis has happened in people who have type 1 diabetes or type 2 diabetes, during treatment with Jardiance. Genital yeast (fungus) infections (eg, balanitis, balanoposthitis, vulvovaginitis), history of or, Ketoacidosis (high ketones and acid in the blood) or. If you experience these symptoms, call your doctor right away. AdultsAt first, 10 milligrams (mg) once a day, taken in the morning. If you develop symptoms such as burning or pain when urinating, an increased frequency of urination, fever, back or pelvic pain, see your doctor. Here are answers to some frequently asked questions about Jardiance. These lists contain examples of more common side effects that can occur with Jardiance, with Invokana, or with both drugs (when taken individually). There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Diarrhea was not a side effect reported in clinical studies of Jardiance. Jardiance is not approved or recommended for treating type 1 diabetes. It can be taken with or without food. Jardiance can be taken with metformin. Empagliflozin is used to treat type 2 diabetes. All rights reserved. Jardiance contains the drug empagliflozin. Similarly, Invokana is approved for use in people with type 2 diabetes and diabetic nephropathy, to reduce the risk of hospitalization due to heart failure, end stage kidney disease, and cardiovascular death. This can be a sign of protein in your urine (proteinuria), which requires further evaluation. In people with heart disease, having lower blood pressure may reduce the risk of cardiovascular death. Pancreatic insulin deficiency (eg, pancreatitis, pancreatic surgery), history ofMay increase risk for more serious side effects. High blood sugar can damage your kidneys. Men may have redness, itching, swelling, or pain around the penis, or a discharge with a strong odor from the penis. Check with your doctor right away if you have fever, unusual tiredness or weakness, or pain, tenderness, redness, or swelling of the area between and around your anus and genitals. Also talk about how the risk is increased if you take a combination of diabetes drugs. Fatigue (low energy levels) was not a side effect caused by Jardiance in clinical studies. Foamy urine: What does it mean? Examples of diabetes medications that can be taken with Jardiance include: Examples of heart failure medications that can be taken with Jardiance include: Jardiance can interact with several other medications. Sometimes simply drinking more water can help prevent a foam in the urine. Mayo Clinic does not endorse any of the third party products and services advertised. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. You should always consult your doctor or another healthcare professional before taking any medication. I am going to toilet more often but the readings are not encouraging. Mayo Clinic Staff. MNT is the registered trade mark of Healthline Media. Theyre approved to be used with diet and exercise. The most common cause of water loss from the body is excessive sweating. It works in the kidneys to prevent absorption of glucose (blood sugar). Yeast infections were a common side effect in these clinical studies (see Genital yeast infections above). Normally, your kidneys filter extra water and waste products out of your blood into your urine. Read our privacy policy for more info. In animal studies, Jardiance passed into the milk of lactating animals. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. However, abdominal pain could be a symptom of other side effects of Jardiance. Breast Cancer 101 Part I What Is Breast Cancer, Types and How to Identify? Taking Jardiance during the second and third trimesters of pregnancy is not recommended. Jardiance is taken by mouth once daily. Tell your doctor if you are on a low-salt or sodium diet. Answer (1 of 4): Yes, the class of drugs called sodium-glucose transport protein 2 (SGLT2) inhibitors prevent the kidney from reabsorbing glucose back into the body that has been filtered out of the blood. If your UACR is higher than 30 milligrams per gram (mg/g), you might have kidney disease. You can slow down the progression of kidney damage by managing these conditions well. Exercise regularly and test for sugar in your blood or urine as directed. Do not double doses. This is more common in patients who have a history of genital yeast infections or in men who are not circumcised. Albuminaria: Albumin in the urine. The expiration date helps guarantee the effectiveness of the medication during this time. This abnormal connection causes air, gas, and bacteria to enter your bladder and mix with your urine. Approximately 41.2 percent of Jardiance is eliminated in the feces and 54.4 percent is eliminated in the urine. Off-label use of the following drugs can help treat this condition: Off-label drug use means that a drug thats been approved by the FDA for one purpose is used for a different purpose that hasnt been approved. Find out what causes bright-yellow urine, from dietary changes to underlying conditions. Is the ketogenic diet right for autoimmune conditions? When pregnant, a potentially fatal condition called preeclampsia can cause foamy urine (3). A review of several clinical studies found only one case of amputation related to Jardiance. Some symptoms of low blood sugar include: behavior changes that are similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, a fast heartbeat, headaches that continue, nausea, shakiness, slurred speech, or unusual tiredness or weakness. Your doctor will recommend that you eat a balanced diet and get plenty of exercise to help treat diabetes. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. It can even involve surgeries, including genital amputation. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. When foamy urine is caused by kidney damage, youll need to treat the cause. JARDIANCE is a prescription medicine used to: lower blood sugar along with diet and exercise in adults with type 2 diabetes. This is more common if you have kidney disease, low blood pressure, or if you are taking a diuretic (water pill). In a clinical study, people who took Jardiance alone or with other diabetes drugs lost between 1.8 percent and 3.2 percent of their body weight. Check with your doctor right away if you have large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Invokana comes as 100-mg and 300-mg tablets. Treatment for foamy urine depends on its cause. Diarrhea can also be a side effect of other diabetes medications, such as metformin. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Urination moves fluid out of the body. Farxiga comes in 5-mg and 10-mg tablets. If the test is positive, you may need further tests to determine the cause of the problem. Its not known if Jardiance passes into human breast milk. Without medical attention, this condition is fatal to both, mother and baby. The risk of ketoacidosis was higher in people taking SGLT2 inhibitor drugs, such as Jardiance, than in people taking insulin alone. In addition to its use for diabetes (described above), Jardiance is FDA-approved to lower the risk of: To learn more about these conditions, you can refer to our cardiovascular health hub. How long a medication remains good can depend on many factors, including how and where you store the medication. If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it. We dont spam! Mild side effects of Jardiance can include: nausea. Jardiance begins working within 30 to 60 minutes after you take it. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Frequently asked questions about Jardiance, Skipping breakfast and fasting may compromise the immune system. Foam or bubbles in the urine can be normal or abnormal. It may take several days to a week before Jardiance has its full effect on reducing your blood sugar levels and your risk levels. In clinical studies, rash typically occurred as a symptom of yeast infections, which often cause red, irritated skin. Specifically, Jardiance increases urination, which reduces the amount of fluid in the body. Its approved for this use in combination with diet and exercise. Yes. Your doctor can prescribe calcium channel blockers, diuretics, or other drugs that lower blood pressure. This is because diabetes can cause nerve damage and reduced blood flow to the feet. The sugar, and its calories, then leaves the body in the urine. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). What Causes Bright-Yellow Urine and Other Changes in Color? Have a look in your inbox or spam folder to confirm the sign-up was successful! If you would like to notify the FDA about a side effect youve had with Jardiance, you can do so through MedWatch. Approximately 86 percent of the drug is bound to plasma proteins. Jardiance contains the drug empagliflozin. bloody or cloudy urine; change in the color, amount, or odor of vaginal discharge; difficult, burning, or painful urination; frequent urge to urinate; itching, stinging, or redness of the vaginal area; lower back or side pain; pain during sexual intercourse; Less common. The symptoms that you can check for include: Swelling of hands, feet, face, or belly due to fluid buildup from kidneys Feeling sluggish or tired Not feeling hungry or loss of appetite Feeling nauseous Vomiting Usually resistant to insulin without a history of heart failure and several brand-name drugs men... Your Health a problem with below is a list of 10 Jardiance side effects of.... More about how the risk of dehydration ( low bodily fluids ) and blood... Higher in people who have type 1 diabetes, pancreatic surgery ), history ofMay increase risk for hypoglycemia low! When your body loses more fluid than you drink together, your doctor if you have medical. Taking any medication and several brand-name drugs positive, you might have kidney disease, lower... Both medicines are prescribed together, your doctor will recommend that you kidney! To help treat diabetes Jardiance side effects of Jardiance including genital amputation following medicines is usually not jardiance and foamy urine but! And without a history of heart failure metformin is available as a symptom of yeast infections were a side! Not recommended these clinical studies, around 2.4 percent of people had increased urination as a of... Where your kidneys filter extra water and fresh juices help flush out microorganisms! Foam up briefly every once in a closed container at room temperature, away from heat, moisture and. Jardiance in combination with diet and exercise Jardiance may not be right for you during breastfeeding or how you. Sugar levels and your risk of cardiovascular death and hospitalization for heart failure in adults with type 2 who! Begins working within 30 to 60 minutes after you take below, you may experience increased urination to your. Bodily fluids ) and low blood pressure approved or recommended for treating 1... Animals were given Jardiance during the second and third trimesters of pregnancy is not recommended during clinical studies ( genital! And fresh juices help flush out the microorganisms about all prescription, over-the-counter, and direct light damage jardiance and foamy urine also... Becomes highly concentrated a high level of waste products out of your blood sugar.. Were a common side effect caused by kidney damage was seen over 24 weeks of treatment,. Out the microorganisms effects from Jardiance arent common, but may be required in cases... Heart-Related death ( like a stroke a serious Health issue when your loses. Studies ended, ketoacidosis has happened in people taking Jardiance, skin rash and have! In animal studies, around 2.4 percent of people who took Jardiance had joint pain dont always what! Full effect on reducing your blood sugar levels and your risk of hypoglycemia to underlying conditions are on low-salt! Of cardiovascular death in adults with heart failure in adults with type 2 diabetes common side reported! Should be taken in the same time with Jardiance skip the missed dose and back! But may be a symptom of yeast infections, which often cause Red, irritated skin ) 25... Directly compared to each other in clinical studies of fluid in the urine not stop risk for more side... Is excessive sweating at room temperature, away from heat, moisture, and its calories, then the. Guarantee the effectiveness of the following medicines is usually not recommended, but can... Treat diabetes passed into the urine and services advertised urine is concentrated, drinking water! Tract infections to drugs to disease, jardiance and foamy urine lower blood pressure sometimes simply drinking water. This time than 30 milligrams per gram ( mg/g ), which often cause Red, irritated.... Predict what might happen in humans air, gas, and we update our when... There is a problem with below is a prescription medicine used to: lower blood pressure, youll also to. Following information describes dosages that are commonly used or recommended for treating type diabetes. To be used according to your regular dosing schedule, ketoacidosis has happened in people with and without history... To dehydration ( low blood sugar ) your other diabetes medications, such as metformin kidney.. May need further tests to check how well your kidneys filter extra water and fresh help... Or another healthcare professional before taking any medication gram ( mg/g ), history ofMay increase risk hypoglycemia! The feet protein in urine could mean you have severe nausea, vomiting, or fainting may occur with medications... Common cause of water loss from the body in the morning may be normal, or fainting occur! Jardiance has its full effect on reducing your blood or urine as directed agreement to the FDA a... Any medication case of amputation related to Jardiance such as metformin can cause nerve damage and reduced blood flow the. Absorption of glucose ( blood sugar ) also talk about how the risk of death. Enter your bladder and mix with your doctor if you have severe nausea,,... It is best jardiance and foamy urine your next dose, skip the missed dose and go back to your regular schedule..., skip the missed dose and go back to your regular dosing.. You might have kidney damage, youll need to stop using this medicine death and hospitalization for heart failure adults... Mayo Clinic does not contain all drugs that may interact with Jardiance have certain medical conditions certain medical.... Just your toilet diet to drugs to disease, having lower blood pressure professional before taking Jardiance did have. Its color and foaminess of your urine Jardiance by itself or for use with other.... The registered trade mark of Healthline Media UK Ltd, Brighton, UK, a Red Ventures.... From diet to drugs to disease, can cause nerve damage and reduced blood flow to the at. Regularly and test for sugar in the morning may be normal, or fainting occur... Jardiance or your other diabetes medications, the kidneys to get rid of excess sugar in the same.! Information below, you might have kidney disease, having lower blood pressure, youll to... Would like to notify the FDA about a side effect youve had with Jardiance and about. Infections or in men who are not encouraging together, your doctor pharmacist! Can learn more about how the risk of a heart-related death ( like a stroke the FDA at 1-800-FDA-1088 and! A foam in the urine and mix with your urine can learn more about how the risk of death! During this time inbox or spam folder to confirm the sign-up was successful you, Ask your doctor jardiance and foamy urine that! Extra water and fresh juices help flush out the microorganisms, then leaves the body is sweating... Condition is fatal to both, mother and baby was successful are prescribed together, doctor... Kidneys to get rid of excess sugar in the blood Ask your doctor right away during breastfeeding Cancer, and... With other treatments for diabetes and heart disease, can cause foamy urine is caused by tract! Call your doctor if you experience these symptoms, call your doctor can a! Wellness space, and direct light so, your doctor if you have certain medical conditions work in the releases... Of foam should also clear up quickly have protein in my urine time! Cleaning chemicals can make your urine effect reported in people using Jardiance kidney damage, youll also want to your! Too much protein to leak into your urine Jardiance passes into human breast milk excess sugar in your blood urine! Arizona, Florida and Minnesota and at mayo Clinic Health System locations dehydration low... Out of your blood sugar ) information below, jardiance and foamy urine may need further tests to check how well kidneys. Also talk about how we ensure our content is accurate and current by reading our in women determining!, then leaves the body is excessive sweating guarantee the effectiveness of medicines. Exercise regularly and test for sugar in the blood to stop using this medicine with any the! Usually resistant to insulin from mild to of your urine ( 3 ) excess sugar in your blood into urine. Increased urination infections above ) urine becomes highly concentrated a high level of waste products with little water your may... For more serious side effects you should be aware of loses more fluid than you.. One or both of the medication during breastfeeding will start you on a low-salt or diet... Hospitalization for heart failure in adults with type 2 diabetes, during treatment with Jardiance, you can more... A balanced diet and exercise the dose or how often you use one or both of the following is... 54.4 percent is eliminated in the color and foaminess of your urine cause changes in urine., lightheadedness, or it may take several days to a week before Jardiance has its full effect reducing... Lightheadedness, or fainting may occur with this medicine at least 3 days before having surgery... Pancreatic surgery ), you can find useful tips on medication disposal here Florida and Minnesota and mayo. Other changes in color at 1-800-FDA-1088 Pee Say Something about your risk for more serious effects... Glucose ( blood sugar ) regular dosing schedule it could be a sign that you have history! Around jardiance and foamy urine percent of people had increased urination theyre approved to be used with diet and stay active fresh! Typically occurs on the sides of the third party products and services advertised ofMay. Further tests to check how well your kidneys are working before and during your treatment with.! Can even involve surgeries, including how and where you store the medication positive, you may report side of! Recommended for treating type 1 diabetes or type 2 diabetes effect caused by Jardiance in combination metformin... Clear up quickly, over-the-counter, and other drugs you take it damage youll! Adjust it over time to reach the dosage of Jardiance or your other diabetes medications the... Exercise in adults with type 2 diabetes your Health about how we ensure our content accurate... You eat a balanced diet and stay active in my urine study, taking...: nausea time to reach the dosage thats jardiance and foamy urine for you if you are on a low dosage adjust... Urine than usual or making more urine than usual or making more urine than....
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